Chronic kidney disease mineral bone disorder in children

Abstract: Childhood and adolescence are critical times for the development of all organs and systems. Achievement of optimal bone mass in this period is thought to be the best predictor for bone health in the adult life1. In children, nutrition, physical activity, growth, endocrine and metabolic function is mandatory for a normal skeleton development and cardiovascular system. Disordered mineral and bone metabolism zassociated with chronic kidney disease causes important obstacles to final adult height, bone strength and cardiovascular integrity that may contribute to chronic morbidity[2, 3]. As kidney function decreases, a progressive deterioration in mineral homeostasis emerge, with an abnormal serum and tissue concentrations of phosphorus and calcium, and changes in circulating levels of hormones[4]. Therefore, treatment target of MBD includes maintaining optimal serum parameters for calcium, phosphorus and parathyroid hormone according to stage of CKD, in order to improve growth, high-turnover bone disease and prevent cardiovascular calcifications.

Keywords: chronic kidney disease, metabolic bone disorder, children