Lungu A.C., Constantinescu Iulia, Stoica Cristina
Abstract: Childhood and adolescence are critical times for the development of all organs and systems.
Achievement of optimal bone mass in this period is thought to be the best predictor for bone health
in the adult life1. In children, nutrition, physical activity, growth, endocrine and metabolic function is
mandatory for a normal skeleton development and cardiovascular system. Disordered mineral and bone
metabolism zassociated with chronic kidney disease causes important obstacles to final adult height, bone
strength and cardiovascular integrity that may contribute to chronic morbidity[2, 3]. As kidney function
decreases, a progressive deterioration in mineral homeostasis emerge, with an abnormal serum and tissue
concentrations of phosphorus and calcium, and changes in circulating levels of hormones[4]. Therefore,
treatment target of MBD includes maintaining optimal serum parameters for calcium, phosphorus and
parathyroid hormone according to stage of CKD, in order to improve growth, high-turnover bone disease
and prevent cardiovascular calcifications.
Keywords: chronic kidney disease, metabolic bone disorder, children
Keywords: chronic kidney disease, metabolic bone disorder, children
2015-03-01