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Update on molecular genetics in acute myeloid leukemia post myeloproliferative neoplasms

Coles Elena Constanta, Stanca Oana, Berbec Nicoleta, Lupu Anca Roxana
Abstract: Myeloproliferative neoplasms (MPN) are indolent hematologic cancers that are characterized by excessive production of mature blood cells. Acute myeloid leukemia (AML) is an uncommon, but often deadly c omplication o f t hese c hronic d isorders. In the last years s ignificant p rogress h as been made in the diagnostic algorithm and therapeutic management of AML postMPN

Keywords: molecular genetics, mutations, myeloproliferative neoplasms, leukemic transformation, acute myelod leukemia


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