Current Issue:
homepage - Therapeutics Pharmacology and Clinical Toxicology
print subscribe
newsletter subscribe

The management of the autoimmune thrombocytopenia associated with chronic malignant lymphoproliferative diseases

Oprea Madalina Marilena, Ivanescu Ana-Maria, Colita A., Turbatu A., Coles Elena, Lupu Anca Roxana
Abstract: Autoimmune thrombocytopenia is a common immune hematologic complication associated with lymphoproliferative diseases, most frequent with chronic lymphocytic leukemia and non-Hodgkin’s Lymphomas . The relation between autoimmune cytopenias and lymphoproliferative malignancies is well known and the mechanisms are complex. Regarding the ethiology, one or more simultaneously occurring causes could leed to thrombocytopenia. We should make a very riguros clinical and paraclinical judgement in diagnosis of autoimmune thrombocytopenia and then, treat not only the number of platelets but also manage the risk of significant bleeding. Supportive care , corticosteroids and chemoimunotherapy are the currently used treatment , individualized for each pacient. The response to the lymphoma treatment is very good, and significant bleeding is rare.

Keywords: imune thrombocytopenia, lymphoproliferative diseases, antiplatelets antibodies


Arhive Category