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The importance of molecular and cytogenetic markers in the prognostic of myelodysplastic syndromes

Nicorescu Iuliana-Maria
Abstract: Myelodysplastic syndromes represent clonal diseases of hematopoietic stem cells that occur predominantly in elderly people, but myelodysplastic syndromes can affect younger patients as well. Myelodysplastic syndromes are characterized by ineffective hematopoiesis, causing different forms of cytopenia in peripheral blood, contrasting normal or hypercellular bone marrow. Although less known, due to its absence from current clinical practice or in the prognostic score, molecular analysis could bring a significant contribution in the early diagnosis of disease. In this respect, the latest studies (2011) show that this type of analysis is of great importance in terms of input added to the pathogenic mechanisms of the Myelodysplastic syndromes subtypes establishment, with high conversion. Furthermore, the analysis serves elect the optimal timing for the initiation of specific therapy.

Keywords: myelodysplastic syndromes, acute leukemias, molecular analysis


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