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The dual role of activated species of oxygen in angiogenesis

Aldea C., Aldea Alina Elena, Negoita Valentina, Anghel Rodica, Gruia Maria Iuliana
Abstract: Lately, the expanding accumulation of scientific data has indicated/demonstrated that malignant tumor growth depends on local angiogenesis. This occurs as a result of a process induced by a subgroup of transformed cancer cells which adopt an angiogenic phenotype, resulting in a new local balance of proangiogenic and antiangiogenic factors. The purpose of our work is to explore the hypothesis that activated species of oxygen play an important role in the pathways that stimulate the angiogenesis favouring tumour growth. The study was performed in vivo, on rats with experimental RS-1 tumours treated with bevacizumabum. We made a dynamic analysis of biochemical parameters of oxydative stress (the level of lipid peroxydes, thyolic groups, total antioxydants); apoptosis was measured by flow-cytometry in tumoral and normal hepatic tissues. We registered a decrease in the oxidative status during the antiangiogenic treatment and a significant increase of apoptosis (from 9.12% to 20.14%) in the malignant cells. These data support the hypothesis that activated species of oxygen can initiate the proangiogenic phenotype transformation. In this kind of oxidative circumstances targeted antiangiogenic drugs can reverse the process and induce tumour cells apoptosis, resulting in clinical benefits for cancer patients.

Keywords: angiogenesis, bevacizumabum, activated oxygen species, experimental tumours, apoptosis


2015-09-01

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